Ralph J DeBerardinis Selected Research

Glutamine (L-Glutamine)

1/2022	SNAT7 regulates mTORC1 via macropinocytosis.
1/2022	Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.
1/2022	Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells.
1/2020	Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model.
1/2020	Using arterial-venous analysis to characterize cancer metabolic consumption in patients.
1/2019	MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.
1/2019	LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma.
1/2018	Lkb1 deficiency confers glutamine dependency in polycystic kidney disease.
1/2016	Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.
1/2016	Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate.

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Ralph J DeBerardinis Research Topics

Disease

86	Neoplasms (Cancer) 01/2022 - 07/2007
13	Lung Neoplasms (Lung Cancer) 01/2021 - 10/2014
12	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 10/2009
9	Glioma (Gliomas) 02/2021 - 03/2011
9	Carcinogenesis 01/2020 - 01/2008
8	Melanoma (Melanoma, Malignant) 01/2022 - 11/2015
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2020 - 12/2015
6	Neoplasm Metastasis (Metastasis) 01/2022 - 11/2015
6	Brain Neoplasms (Brain Tumor) 01/2019 - 09/2011
5	Hypoxia (Hypoxemia) 01/2022 - 05/2007
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 01/2015
4	Renal Cell Carcinoma (Grawitz Tumor) 11/2021 - 11/2011
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 06/2014
3	Hepatocellular Carcinoma (Hepatoma) 11/2021 - 01/2019
3	Colonic Neoplasms (Colon Cancer) 01/2019 - 07/2007
3	Adenocarcinoma 11/2017 - 01/2015
2	Disease Progression 01/2021 - 08/2017
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2021 - 01/2019
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2019 - 01/2016
2	Leukemia 10/2015 - 08/2014
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Triple Negative Breast Neoplasms 01/2022

Drug/Important Bio-Agent (IBA)

27	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 05/2007
23	EnzymesIBA 01/2022 - 11/2012
23	Glutamine (L-Glutamine)FDA Link 01/2022 - 10/2009
17	Lactic Acid (Lactate)FDA LinkGeneric 01/2022 - 05/2007
12	CarbonIBA 01/2021 - 12/2007
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2007
10	Pyruvic Acid (Pyruvate)IBA 11/2021 - 11/2012
9	Oxidoreductases (Dehydrogenase)IBA 01/2022 - 03/2011
8	LipidsIBA 01/2022 - 12/2007
8	Biological ProductsIBA 11/2021 - 09/2013
8	Biomarkers (Surrogate Marker)IBA 02/2021 - 10/2013
7	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 01/2014
7	IsotopesIBA 11/2021 - 01/2015
6	NucleotidesIBA 01/2022 - 12/2007
6	NADP (NADPH)IBA 01/2022 - 03/2011
6	alpha-hydroxyglutarateIBA 01/2020 - 03/2011
5	Adenosine Triphosphate (ATP)IBA 01/2022 - 05/2014
5	Citric Acid (Citrate)FDA LinkGeneric 01/2022 - 11/2011
5	GlutaminaseIBA 01/2022 - 05/2011
5	AntioxidantsIBA 02/2021 - 01/2015
5	Glutamic Acid (Glutamate)FDA Link 01/2021 - 01/2015
5	Phosphotransferases (Kinase)IBA 12/2020 - 01/2016
5	Amino Acids FDA Link 01/2020 - 12/2008
5	Serine (L-Serine)FDA Link 01/2020 - 09/2011
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 10/2014
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2022 - 03/2011
4	CytokinesIBA 01/2021 - 11/2015
4	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2020 - 09/2011
4	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2015 - 11/2011
3	Glutathione (Reduced Glutathione)IBA 01/2022 - 10/2013
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 11/2021 - 11/2012
3	Inosine Monophosphate (IMP)IBA 01/2021 - 01/2018
3	Tricarboxylic AcidsIBA 01/2021 - 11/2018
3	pyrimidineIBA 12/2020 - 01/2017
3	Pharmaceutical PreparationsIBA 10/2020 - 11/2015
3	DNA (Deoxyribonucleic Acid)IBA 05/2019 - 11/2015
3	RNA (Ribonucleic Acid)IBA 01/2019 - 12/2014
3	beta-lapachoneIBA 11/2017 - 01/2015
3	Fumarate Hydratase (Fumarase)IBA 10/2013 - 11/2011
3	isocitric acid (isocitrate)IBA 11/2012 - 03/2011
2	CarbohydratesIBA 01/2022 - 11/2018
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2022 - 10/2015
2	Pyruvaldehyde (Methylglyoxal)IBA 11/2021 - 12/2019
2	GuanosineIBA 01/2021 - 01/2018
2	Large Neutral Amino Acid-Transporter 1IBA 01/2021 - 01/2019
2	Branched-Chain Amino AcidsIBA 01/2021 - 01/2019
2	Messenger RNA (mRNA)IBA 01/2021 - 05/2007
2	NitrogenIBA 12/2020 - 03/2011
2	Carrier Proteins (Binding Protein)IBA 12/2020 - 01/2017
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 05/2007
2	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 01/2020 - 11/2012
2	Glycine Dehydrogenase (Decarboxylating)IBA 01/2020 - 12/2019
2	NAD (NADH)IBA 01/2020 - 11/2015
2	Pyruvate CarboxylaseIBA 12/2019 - 05/2011
2	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2017 - 12/2014
2	AcidsIBA 01/2017 - 01/2016
2	Epidermal Growth Factor (EGF)IBA 12/2016 - 08/2014
2	Acetates (Acetic Acid Esters)FDA Link 01/2016 - 12/2014
2	Metformin (Glucophage)FDA LinkGeneric 12/2015 - 07/2007
2	Phosphogluconate Dehydrogenase (Dehydrogenase, Phosphogluconate)IBA 11/2015 - 08/2014
2	Small Interfering RNA (siRNA)IBA 02/2015 - 11/2012
2	Ketoglutaric Acids (Ketoglutaric Acid)IBA 02/2015 - 06/2014
2	Glutamate DehydrogenaseIBA 02/2015 - 10/2009
2	Monocarboxylic Acid TransportersIBA 12/2014 - 11/2014
2	Oxygen (Dioxygen)IBA 11/2012 - 12/2007
1	Gabapentin (Neurontin)FDA LinkGeneric 01/2022
1	AsparagineIBA 01/2022
1	branched-chain-amino-acid transaminaseIBA 01/2022
1	Estrogen ReceptorsIBA 01/2022
1	GTP Phosphohydrolases (GTPases)IBA 01/2022
1	Indicators and Reagents (Reagents)IBA 11/2021
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 11/2021
1	Superoxide DismutaseIBA 02/2021
1	MicroRNAs (MicroRNA)IBA 02/2021

Therapy/Procedure

19	Therapeutics 11/2020 - 12/2008
2	Immunotherapy 01/2021 - 01/2021
1	Precision Medicine 11/2021
1	Catheters 11/2021